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[DOI] [PMC free article] [PubMed] [Google Scholar] 196.Konarkowska B., Aitken J.F., Kistler J., Zhang S., Cooper G.J.S

Oleanolic acid-derived bardoxolone methyl, a dual activator of Nrf2 and inhibitor of the NF-B pathway, entered clinical trials for the treatment of diabetic nephropathy and chronic kidney disease (de Zeeuw et al

It is synthesized primarily in the liver, though individual cells can help regulate their own intracellular glutathione levels based on metabolic need
For those just tuning in, the context matters enormously because without it, the headlines can be wildly misleading

doi: 10.1016/s0306-3623(97)00418-7
