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This result was in keeping with the one reported in a recently published paper [178]

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These findings may explain the beneficial effects of selenium supplementation in autoimmune thyroid diseases (181, 194), such as reduced levels of anti-thyroid antibodies, improved thyroid structure and metabolism, and ameliorated clinical symptoms (181, 195)

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Further analysis identified that the core metabolite N,N,N-trimethyllysine, a precursor of L-carnitine, was associated with 16 known proteins, including UBAP2, ATP2A2, LGALS3, SLC25A13, ACSS1, AGPAT5, RASA4, MTERF2, DPYSL3, INPP5K, BCKDHA, TKFC, ACSF2, SERPINA3-7, PNPLA6, and GYS1 (Fig