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They're dose-dependent and occur predictably

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Formulation adjustment can maximize the amount of moisture that can be held in a product at the water activity specification through the addition of humectants such as sugar, salt, and glycerin, which lower water activity without the removal of moisture

DOI: 10.1016/s0928-4257(99)00120-5 10.1016/s0928-4257(99)00120-5 Sikiric.P, Seiwerth.S, Rucman.R, Turkovic.B, Rokotov.D, Brcic.L, Sever.M, Toxicity by NSAIDs