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However, a 2020 report highlights that further research is necessary to understand the potential role of vitamin B12 in the development of diabetes

doi: 10.1186/1742-2094-9-68

Strategies that deplete GSH, such as using inhibitors like BSO which is inhibitor of -glutamylcysteine synthetase (-GCS) , the rate-limiting enzyme in glutathione (GSH) synthesis or by combining prodrug activation with GSH depletion in nanosystems, have shown promise in overcoming MDR and improving chemotherapy effectiveness [72]

The resulting metabolites can be more toxic or reactive, and these reactions can also generate intermediates that may cause damage to hepatocytes or other cells in the liver