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Research progress Support The animal experiments have achieved remarkable results: In the obese mouse model, after daily subcutaneous injection of AOD 9604 (250 g/kg) for 8 weeks, the body weight of the mice decreased by 12%, the subcutaneous fat mass decreased by 25%, and the weight of epididymal adipose tissue significantly decreased, confirming its effectiveness in fat reduction

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[73] demonstrated that a 6-month supplementation with vitamin B12 improved the symptoms of diabetic neuropathy, regardless of the mode of administration (intramuscular or oral)

Genetic variants affecting GH signaling, telomerase activity, or metabolic pathways might predict responsiveness to corresponding peptides, enabling targeted rather than universal interventions ( Regulatory pathways specifically designed for aging interventions could accelerate clinical development

The molar ratio was 1.5 biotin per hHGF as determined using a Biotin Quantitation Kit (Pierce)