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Description
Lower variability in drug exposure facilitates more predictable dose-response relationships and simplifies dose selection in clinical practice

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To inactivate the dihydrolipomide dehydrogenase of the pyruvate dehydrogenase complex, arsenite, a sulfhydryl reactive metalloid, can covalently attach to the vicinal dithiols [242] or sulfhydryl groups of Lipoamide (a cofactor of dihydrolipoyl dehydrogenase enzyme) [243]

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[DOI] [PubMed] [Google Scholar] 48.Huang S
