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Hyperhomocysteinemia (elevated levels of homocysteine in the blood) is a risk factor for the development of cardiovascular disease and neurodegenerative diseases including dementia, AD, and Parkinsons disease (PD) (Seshadri et al., 6, or vitamin B 12 (Clarke et al., N -methyl D aspartate (NMDA) receptors to cause excitotoxicity, acting as an agonist at the glutamate binding site as well as a partial antagonist of the glycine co-agonist site (Lipton et al., 2014)

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Cognitive Decline & Mild Cognitive Impairment Cognitive Decline & Mild Cognitive Impairment Last Section Update: 07/2026 Contributor(s) : Shayna Sandhaus, PhD

Here are some tips for optimizing your glutathione supplementation: 1