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Additional insights come from studies on allergies to snail, a mollusk with cross-reactivity to HDM [78, 79]

Consequently, although adjuvant benefits have been demonstrated for formulations such as VSL#3 (Tursi et al., 2010), and synbiotics can modulate the microbiota and improve mucosal status (Ishikawa et al., 2011), the durability of these effects and the optimal implementation strategyincluding patient selection, timing, and combinationsremain uncertain

JAMA 331(1):3848

Management strategies for gastrointestinal side effects include eating smaller meals, avoiding high-fat foods, staying well-hydrated, and taking the injection at bedtime so peak drug levels occur during sleep

It makes it a targeted therapy with a specific rationale , and one that deserves careful, evidence-aware discussion