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Oxidative stress, DNA damage, and antioxidant enzyme activity induced by hexavalent chromium in Sprague-Dawley rats
In cancer, CDO has been shown to divert the flow of cysteine away from glutathione synthesis, thereby promoting the production of ROS
Several candidate non-glutathione disulfide substrates for the dithiol mechanism have been identified using monothiol glutaredoxin mutants as bait proteins for the trapping of Grx(SSR) species (Fig
Science 249 , 505510
[PubMed 5953067] 101
