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Through extensive analysis of publicly available databases, we demonstrated that the HER2ELF3KRAS axis is selectively activated in KRAS G13D CRCs (Fig

This review highlighted some of the pericyte metabolic pathways and how they are impacted by chronic hyperglycemia, leading to oxidative stress, AGE accumulation, inflammation, and mitochondrial dysfunction

No cancers have been attributed to IGFBP gene mutations, but some might be associated with epigenetic silencing of IGFBP gene expression (in particular, IGFBP3 )

Furthermore, hypoxia-recruited tumor-associated macrophages (TAMs) in the TME release factors that contribute to drug resistance and cancer cell survival (196)