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Notably, Molidustat robustly stabilises HIF-1 and induces VEGF to levels comparable to hypoxia, presenting an opportunity for combination strategies that counterbalance HIF-driven angiogenesis

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Overall, these studies suggest that fisetin exerts antitumor effects in ovarian cancer, including induction of apoptosis and necroptosis, inhibition of anti-apoptotic proteins, and reversal of chemotherapy resistance (Figure 6 and Table 1)
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