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Whilst 510% of patients taking VPA may develop a transient alanine transaminase rise, numerous cases of acute liver injury presenting with jaundice and progression to fatal liver failure have been reported, with most cases occurring within the first 6 months of treatment

Evidence: A 2024 review noted it helps strengthen the heart muscle and improve its pumping efficiency

[3] Sinclair C, Gilchrist J, Hennessey J, et al

Profiles of Drug Substances, Excipients and Related Methodology (2023)

A meta-analysis of 15 case-control studies identified that Ruminococcaceae, Bifidobacteriaceae, Christensenellaceae and Verrucomicrobiaceae were enriched in PD patients