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Depletion of MSCs and inefficient cell signaling can be detrimental to aging changes

Several practical unknowns compound this

A fully human monoclonal antibody, Cosentyx, which works by targeting and inhibiting the IL-17A cytokine, thereby suppressing the inflammatory pathway, was previously only authorized as a subcutaneous treatment in these indications

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Chronic dosing studies including protocols running daily administration for 4 to 12 consecutive weeks have not documented significant organ toxicity markers at doses ranging from 10 to 100 g/kg