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Description
CBS catalyses the conversion of L-homocysteine into L-cystathionine by displacing the OH group of L-serine with the thiol of L-homocysteine in a -replacement reaction to form L-cystathionine, which is subsequently hydrolysed by cystathionine -lyase (CSE) into L-cysteine
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A 2024 review surveyed neurotransmitter-system interactions in this body of work (PMID 38675421), suggesting the compound's effects on central nervous system tissue may share mechanisms with its peripheral activity
Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/-catenin antagonists against human osteosarcoma cells
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