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Kim S, Jhong J-H, Lee J, Koo J-Y (2017) Meta-analytic support vector machine for integrating multiple omics data

We found that intracellular 1-MNA and NNMT protein expression levels were substantially higher in the fully differentiated adipocytes compared to the undifferentiated pre-adipocytes, which is consistent with the differentiation-dependent enhancement in NNMT mRNA levels and enzymatic activity reported previously in the 3T3-L1 cell lines.[37] The higher levels of 1-MNA and NNMT in adipocytes compared to pre-adipocytes may partially account for our observations that increasing concentrations (10 60 M) of NNMT inhibitor did not completely eliminate 1-MNA in adipocytes, but did fully suppress 1-MNA accumulation in undifferentiated pre-adipocytes

Desalination 537 , 115876 (2022)

point out that AED and AEDG suppress caspase-dependent apoptosis, which increases as cell cultures age [66]

They slow gastric emptying so food sits in the stomach longer, creating a physical sensation of fullness