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MOTS-c activates AMPK pathways that improve GLUT4 glucose transport, restoring cellular glucose uptake without the GI side effects of metformin.5 For adults managing prediabetes or metabolic syndrome, this is clinically significant

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However, no individual region was significantly different in the pair-wise comparisons, which could reflect the fact that the expression of 5-GABA A Rs is lower in these regions [33]