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doi: 10.1186/s12245-018-0205-8

Reduced insulin sensitivity, with increases in fasting blood glucose and HbA1c relative to placebo over 12 months in the same controlled trial, a concern for anyone with existing metabolic risk

SandbornWJColombelJFEnnsRFeaganBGHanauerSBLawranceICet alNatalizumab induction and maintenance therapy for Crohns disease

16,47 However, a reliable estimation can be made by comparing brain uptake after intranasal and intravenous administration