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2015-0004) and was performed in accordance with the Declaration of Helsinki (23)

The study also points out that some preclinical benefits, such as lower ALT and TGs, have not been consistently seen in clinical trials, and many animal studies have used doses that are hard to replicate in people, creating translational hurdles

13(1): 121 De Simone C, Moretti S, Marcellini S, et al

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Some individuals notice appetite changes within weeks, but meaningful weight loss typically becomes noticeable after several weeks to a few months of consistent use, particularly when paired with nutrition and exercise adjustments