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In one embodiment of the invention, the further active ingredient is a modulator of the cystic fibrosis transmembrane conductance regulator (CFTR) as described e.g

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Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

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Dermoscopically, a depigmented scar-like area, multiple homogeneous areas (particularly when variable in size or when more than 25% of the lesion is involved), a whitish veil, radial streaming, and black dots of variable size and irregular distribution suggest a melanoma

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