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Key distinctions between these two pathways include the need for molecular oxygen to aid in ring contraction and cobalt insertion: in the aerobic pathway, this occurs only after the synthesis of hydrogenobyrinic acid a , c diamide (late stage), whereas in the anaerobic pathway (as shown in Figure 3), it occurs at the precorrin2 stage (early insertion)

Nature 548(7669):602 Zeiser R, Maas K, Youssef S, Drr C, Steinman L, Negrin RSJI (2009) Regulation of different inflammatory diseases by impacting the mevalonate pathway