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The presence of copper in this tripeptide is critical, since copper is an essential trace element for collagen production, wound healing, and enzymatic activity in the skin

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Am J Kidney Dis 32:10001010 Isshiki K, He Z, Maeno Y, Ma RC, Yasuda Y, Kuroki T, White GS, Patti ME, Weir GC, King GL (2008) Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells