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Notably, no effect of high-dose folic acid (5 mg/day) for 3-months on blood MMA concentrations was observed in a cohort of middle-aged individuals (82)

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doi: 10.1002/(SICI)1097-4652(200006)183:3 3.0.CO;2-N

An increase of pro-inflammatory markers such as interleukin (IL)-1, IL-6, and TNF- leads to an upregulation of matrix metalloproteinases (MMP), particularly increased in chronic wounds [95]

Furthermore, certain medications, like proton pump inhibitors for acid reflux, metformin for diabetes, and some medications for peptic ulcers or heartburn, can impair your bodys ability to process Vitamin B12
