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As you age, these telomeres naturally get shorter, which can lead to cellular aging and decline

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Serious adverse effects have not shown up in the research literature

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doi: 10.1038/s41598-022-18195-8

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Similarly, another smaller study, BEDIP, with a shorter duration, found improvements in a combined neuropathic symptom and sign score after 3 weeks of treatment with 400 mg of benfotiamine daily [72]

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Myelin regeneration faces several specific challenges including a highly inflammatory environment hostile for newly formed OPCs (discussed below) and the less plastic adult/aged OPCs

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