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All experiments were carried out in accordance with the Guide for the Care and Use of Laboratory Animals [20] and with approval from the Institutional Animal Care and Use Committee at the University of Texas Medical Branch

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Drug Categories Experimental metabolic modulator, NNMT inhibitor, anti-obesity agent, muscle regenerative enhancer

In contrast, DIO mice in both groups switched from WD to LD each had significantly increased Proteobacteria relative abundance (represented solely by the genus Parasutterella ) compared to both the WD and the LD controls, suggesting that Proteobacteria relative abundance may be largely influenced by stress or the differences in net energy expenditure (or associated body weight changes) caused by the diet switch

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