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Description
Polyunsaturated fatty acids (PUFAs) on the cell membrane can be oxidized by one or more lipoxygenases (LOXs), which contain di-iron active sites to form lipid peroxides (L-OOH)

Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies
J Clin Oncol 21 (9): 1798-809, 2003
Furthermore, in these cells, the mTOR regulation of the ATP synthesis pathway was disrupted

doi: 10.1371/journal.pone.0138318 143
