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Given these challenges, there is an urgent need for the development of new experimental models that more accurately reflect the human CNS environment, as follows: 1) Innovative in vitro models: Developing advanced 3D culture systems or organoid models that replicate the cellular architecture and microenvironment of the CNS could offer more relevant insights into HIV-1 interactions with microglia and other brain cells

119 GLP-1 receptor agonists (e.g., liraglutide and semaglutide) are approved for the treatment of T2DM and obesity, which can reduce body weight and IR, lower CVD risk, delay CKD progression, and even prevent stroke

[DOI] [PubMed] [Google Scholar] 124.Ishizuka M., Ohtsuka E., Inoue A., Odaka M., Ohshima H., Tamura N., Yoshida K., Sako N., Baba T., Kashiwabara S., et al

Chouli, M., Bothou, A., Kyrkou, G., Kaliarnta, S., Dimitrakopoulou, A., & Diamanti, A

Some researchers have reported that the rate of ALA uptake is not affected by the time the stomach is emptied, as found in a study conducted in insulin-dependent diabetic patients, in whom no particular effect on ALA bioavailability was observed [93]