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4.2 Gut microbiota dysbiosis and abnormal activation of complement C4 Genetic susceptibility to schizophrenia is significantly associated with polymorphisms in genes related to the complement system, largely attributable to alleles of the complement C4 gene located within the major histocompatibility complex region on chromosome 6 (132)

Not surprisingly, and in agreement with findings from B

The association is stronger in men and current smokers [377,378]

Crosstalk between DA and PD genes in PD pathogenesis Although most PD cases are sporadic, familial forms of PD caused by genetic mutations account for about 5%10% of PD cases

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