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The final autopsy did not show any pathological changes in various organs
Related article: Methylation cycle report (MTHFR, COMT, B12, and more) Methyl groups are used to: Form new molecules, including neurotransmitters Control DNA gene expression (turn on and off genes) Detoxify certain substances Lets look at each of these: 1

The first hypothesis was proposed by Gilliam and Cox,5 who reported that patients with vitamin B12 deficiency had decreased levels of reduced glutathione (GSH)

The mechanism appears to involve stimulation of hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) activity, leading to accelerated triglyceride hydrolysis and increased free fatty acid release
Can Vitamin B12 Deficiency Explain Fatigue