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Another characteristic of PD is oxidative DNA damage, which triggers PARP activation, leading to the depletion of NAD + levels 40,279,282,283,284

GO biological process analysis indicated enrichment primarily in ECM organization, extracellular structure organization, and external encapsulating structure organization

This may limit the therapeutic potential of ADI as an arginine depleting agent for cancer treatment

Mov Disord off J Mov Disord Soc 32:16311636 [DOI] [PMC free article] [PubMed] [Google Scholar] Zhang S et al (2015) Plasma homocysteine, vitamin B12 and folate levels in multiple system atrophy: a case-control study

Potentiation of ethanol-induced hepatic vitamin A depletion by phenobarbital and butylated hydroxytoluene