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However, these approaches have limitations in accurately evaluating fibrotic activity and progression, as they are indirect measure of disease outcome 10,11

however, 3 69-VNP levels showed steady increases over time without detectable rhythms

After full recovery, correct cannulation was tested by observing water drinking responsiveness after infusion of 1 l human angiotensin II (Sigma-Aldrich, A9525) at a concentration of 24 M in artificial cerebrospinal fluid (distilled water with 125 mM NaCl, 2.5 mM KCl, 2.6 mM NaHCO 3 , 1.25 mM NaH 2 PO 4 2H 2 O, 25 mM d-glucose monohydrate, 1 mM MgCl 2 , 2 mM CaCl 2 )

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A deficiency can lead to symptoms like lethargy and weakness, making it harder to tackle daily tasks