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RNS are present in high levels due to the action of the i-NOS enzyme, produced locally due to inflammation

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For example, ORMDL3 mRNA expression is significantly upregulated in serum samples from AD patients

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The low HDL cholesterol and high triglyceride concentrations measured before or during hospitalization are strong predictors of a severe course of the disease

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On the other hand, patients with neurofibromatosis type 1 (NF-1) have a lifetime risk of developing an MPNST of 8-13%.3 The 2- and 5-year overall survival rates are 57% and 39%, respectively

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