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But the primary concern is the risk of ochronosis, a rare but challenging condition where long-term overuse paradoxically causes darkening of the skin, says Francesa Lewis, MD, a board-certified dermatologist in Delray Beach, Florida

Anson BD, Weaver JG, Ackerman MJ, Akinsete O, Henry K, January CT, et al

All patients fulfilled the clinical definite criteria for MS.[2] None of the patients had the history of atrophic gastritis or gastrectomy and none of them had anemia or malnutrition on vegetarian diet or chronic alcohol abuse

Wu, H., Gong, J
Lancet (1987) 1(8539):9524
