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* Correspondence: Grgory Bouchaud [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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While it is intuitively assumed that antioxidants emerged during the GOE to defend against O 2 reactivity and toxicity caused by the accelerated oxygenation of the atmosphere, sequencing and phylogenetic analyses of antioxidant systems from ancient organisms suggests that antioxidant enzymes including SODs may have originated long before the surge of atmospheric and oceanic O 2 (Wolfe-Simon et al

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