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Additionally, TMAO induced hypertension by accelerating vascular endothelial dysfunction (124)

The underlying cause of renal dysfunction, therapeutic interventions prevalent in CKD patients (e.g., antibiotics and immunotherapy), CKD-specific treatment interventions such as iron supplementation and phosphate binders (Dostal et al., 2015), and dietary restrictions (Wong et al., 2014) have all been linked to these shift patterns

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Short chain fatty acids (SCFAs) are one prospective factor contributing, as they have the ability to regulate blood pressure via G protein-coupled receptors (GPCRs) (Yang et al., 2015)