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Its ability to orchestrate adaptation to oxidants and electrophiles is due principally to stress-stimulated modification of thiols within one of its repressors, the Kelch-like ECH-associated protein 1 (Keap1), which is present in the cullin-3 RING ubiquitin ligase (CRL) complex CRL Keap1

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The sulfur-containing amino acids: an overview
It then closes up, to prevent the food from returning up the food pipe