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In addition, PTMs regulate interactions with other cellular molecules, including proteins, nucleic acids, lipids, and cofactors

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Mutations in SMARCA5 can cause chromatin condensation, reducing the nuclear permeability of chemotherapeutic agents ( 2.4 Non-coding RNA regulation Non-coding RNAs (ncRNAs) are critical regulators of gene expression and chromatin structure in AML, particularly in the development of drug resistance

Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers

10.1186/s12886-021-02079-y 34 ShaheenA.Gallo AfflittoG.SwaminathanS