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S.ZhangB

Elevated levels of 2-hydroxyglutarate, a metabolite associated with the TCA cycle, may promote tumorigenesis [51]

[DOI] [PubMed] [Google Scholar] 33.Vally H, Thompson PJ

doi: 10.1002/jcc.21334

In particular, the canonical NF-B pathway, which controls several aspects of cell growth and survival, inflammation, and immune response, is implicated in the regulation of thyroid physiology, participating in the expression of various thyroid-specific genes, including NIS , PAX8 , TG , TPO , and TTF-1 , and also contributes to the development of several neoplasms, including TC, enhancing the proliferation and viability of thyroid neoplastic cells and their potential to migrate and colonize distant sites [128,129,130]