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In some patients, especially those with thicker subcutaneous fat, injections given in this area may also fail to reach the muscle properly, which can affect medication absorption

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Bioavailability and daily requirement of vitamin B12 in adult humans: an observational study of its colonic absorption and daily excretion as measured by [13C]-cyanocobalamin kinetics

Compounding also does not make an otherwise investigational peptide FDA-approved

The short answer is: Be careful with layering
