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Beyond that, the evidence is per-compound plus the CagriSema (cag + sema) Phase 3 data as the closest human analog

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Modern pharmacological studies have shown that Er-zhi pills can increase melanin leves and TYR activity in both zebrafish depigmentation model and B16F10 cells by activating the cAMP/PKA signalling pathway [79]

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In addition to the use of TKIs combined with PD-1/PD-L1 inhibitors, dual immunotherapies (ipilimumab with nebuliumab and atrilizumab with bevacizumab) are currently used for the first-line treatment of advanced renal cancer (166)