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This review highlights the prevalence, molecular mechanisms and combating approaches of underlying risk conditions by managing endothelial dysfunction, hypertension, and platelet hyperactivity/prothrombotic state with bioactive compounds like polyphenols, small molecules like miRNA, and gene therapy

The underlying chronic inflammatory state is therefore expected to exacerbate pain through mechanisms similar to those described in other inflammatory disorders

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doi: 10.1016/j.freeradbiomed.2024.02.028 104 PlutaR.JanuszewskiS.CzuczwarS

The chondral defect (4 mm in diameter) was created in the trochlear groove of the distal femur according to a previously described method [24]