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doi: 10.1002/brb3.1293

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No completed, peer-reviewed human efficacy or long-term safety trial exists as of 2026

Belhage B, Hansen GH, Meier E, Schousboe A

NAD+ affects at least six hallmarks of aging through sirtuin activation, including DNA repair, mitochondrial function, epigenetic maintenance, nutrient sensing, autophagy, and stem cell function