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The resulting suboptimal homeostasis of GSH results in a decreased capacity to minimize oxidative stress, which is associated with poor outcomes during ageing and in multiple disease states

pneumoniae disseminated bacteremically to these organs within less than 24 hours following the onset of pneumonia

169 Although he did not connect this rise with the use of acetaminophen in neonates and children, the widespread use of acetaminophen in infants, neonates, toddlers, and small children began in the early 1980s as a result of the discovery that aspirin may be associated with Reye syndrome

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The reversible reduction of GSSR substrates usually requires only the first active-site cysteinyl residue and is therefore catalyzed by a monothiol mechanism with ping-pong bi-bi kinetic patterns (Fig