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These findings suggest oral administration can be effective, at least in rodent models

Researchers hypothesize that the elevated NAD+ levels increase futile cycling a process where cells burn energy to maintain electrochemical gradients rather than storing it as lipid droplets

That action spares nicotinamide for NAD+ production and preserves SAM, which in cell and animal studies translates to reduced fat storage, smaller fat cells, and higher cellular energy output

This connects it to longevity research involving [Epithalon] and other epigenetic modifiers

Mice tolerated doses several times higher than the effective dose with no observable adverse effects