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Adems, el IGF-1 es clave para el crecimiento seo en pacientes peditricos, actuando directamente en condrocitos, osteoblastos y en menor medida en osteoclastos
Posibles efectos secundarios Dado que 5AM an es experimental, los efectos secundarios documentados se limitan a observaciones preclnicas

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Originally proposed in 1976 as a new treatment for Crigler-Najjar syndrome type 1 and validated in hyperbilirubinemic Gunn rat models, HTx has undergone substantial advances over time (Matas et al., 1976)
