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Environmental factors that may contribute to the development of AITDs include the amount of iodine intake, consumption of gluten and alcohol, deficiencies in selenium, iron, zinc, and vitamin D, high levels of stress, pregnancy, and the use of key immune modulators such as interferon, ipilimumab, and alemtuzumab (21)

Moreover, ROS is a crucial link between the NF-B and JNK signaling pathway

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