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employed an in vitro BEAS-2B cells to explore the intracellular signaling pathways involved in IL-6 production induced by LPS and Ni NPs (Fig
10.1038/s42255-020-0172-2

Nevertheless, administering all four doses of oral HDV-I did not result in a noteworthy decrease in the incremental plasma glucose AUC values, when compared to that observed in the placebo at either 2 or 4 h after lunch and dinner

S.NorstedtG.BillestrupN.WhiteM
One quick answer is calorie restriction or some form of it
