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10.1038/178064a0 27 HuemerM.DiodatoD.SchwahnB.SchiffM.BandeiraA.BenoistJ

Intranasal administration has been shown in animal and some early human work to cross into the system and produce measurable effects on sleep-related endpoints

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Similarly, hypophysectomy in humans results in a rapid decrease in GFR, even when patients receive hormone replacement for all pituitary deficiencies, except GH [130]
