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While mutations of ETC proteins are rarely linked as a direct cause of PD (except for UQCRC1), impaired ETC proteins may not only lead to excessive ROS production, but also cause impeded mitophagy, -Syn aggregation, and apoptosis in PD pathogenesis

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This entails tweaking fermentation settings, modifying Pseudomonas dentifrices strains genetically, and incorporating precursor chemicals or other precursors into the fermentation media