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The PINK1/Parkin is a critical mediator in the classical mitophagy pathway and has been extensively studied ( In vivo experiments further confirmed that FLIPUS could alleviate ECM loss and chondrocyte apoptosis in a destabilization of the medial meniscus (DMM) mouse model through mitophagy mediated by FUNDC1, thereby exerting a protective effect on cartilage ( FIGURE 2 4 Mitophagy and metabolic diseases The specific pathogenesis of metabolic diseases has not been conclusively determined, and it is currently believed that potential mechanisms such as ROS surge, abnormal protein structure and function, chronic low-grade inflammation, DNA damage, and insulin resistance are closely related to mitochondrial dysfunction (Table 1)

N-acetylcysteine (NAC) is an antioxidant that reduces intermittent hypoxia resulting from excitation of the sympathetic nervous system

66 Recently, supercritical carbon dioxide (scCO 2 ) has attracted much attention due to its lower critical temperature (31.1C) and critical pressure (73.8 bar) to solubilize some specific polymers, and the interactions of scCO 2 with the active ingredient, polymeric materials and solvents should be considered in microsphere fabrication

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All values are literature-reported approximations for research reference