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GPX4 also exhibits activity to inhibit inflammatory NFKB pathway activation and proinflammatory mediator production (e.g., production of IL1B and PTGS2/COX2 [prostaglandin-endoperoxide synthase 2]) in various experimental models, such as angiogenesis and hair follicle development [25,178]

Cell Death Dis 2013;4:e626 [DOI] [PMC free article] [PubMed] [Google Scholar] 43.Ye D, Wang Y, Li H, Jia W, Man K, Lo CM, Wang Y, Lam KS, Xu A.Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1alpha-mediated antioxidant capacity in mice